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Amoxicillin and Co-Amoxiclav (High Dose Therapy)

Drug Class: Commonly Known As: Category:
Antibiotic Amoxil, Augmentin, Augmentin ES Children

Amoxicillin and Co-Amoxiclav (High Dose Therapy) - Dosage and How to Use

How should Amoxicillin and Co-Amoxiclav (High Dose Therapy) be used?

​Amoxicillin or Co-amoxiclav/Amoxicillin-Clavulanate is usually taken two or three times a day.

Do note that the information leaflet or medicine label that comes with a medicine mostly relates to adults or common indications. The dose your child will require will vary depending on your child's weight, type and severity of infection, and hence may appear different from the manufacturer's recommendation.

Follow the doctor's and/or pharmacist's instructions about how and when to give. Do not stop taking this medicine unless instructed by the doctor. Stopping this medicine can worsen the infection or result in resistance.

What should I do if I miss a dose?

  • Take the dose as soon as it is remembered and then continue to take it as one normally would. However, if it is almost time for the next dose, skip the dose that is missed and administer the next dose at the usual time.
  • Do not double or increase the dose.

What should I do if I overdose?

Amoxicillin and Co-Amoxiclav (High Dose Therapy) - Handling and Storage

How should I handle Amoxicillin and Co-Amoxiclav (High Dose Therapy) safely?

How should I store Amoxicillin and Co-Amoxiclav (High Dose Therapy)?

How should I dispose of Amoxicillin and Co-Amoxiclav (High Dose Therapy) safely?

Amoxicillin and Co-Amoxiclav (High Dose Therapy) - Additional Information

Why does my child require high-dose Amoxicillin or Co-amoxiclav/ Amoxicillin-Clavulanate (Augmentin®)?

High-dose amoxicillin (i.e. 80 to 90mg/kg/day) is usually prescribed for the treatment of certain infections, such as the following:

  • Chest (pneumonia),
  • Ear (otitis media), and/or
  • Sinuses (sinusitis)

The most common bacteria that causes these infections is known as Streptococcus pneumoniae. However, over the years, the effectiveness of antibiotics (such as amoxicillin) against Streptococcus pneumoniae has been reduced, as the bacteria change or mutate (i.e. develop antibiotic resistance). This can potentially lead to treatment failures. 

Hence, it is now recommended that high-dose Amoxicillin (80 to 90 mg/kg/day) be used to overcome this antibiotic resistance, to allow a more effective treatment of these infections. As a result, the volume of antibiotics that your child has to take may sometimes be of a larger volume.   

​Click here for more information on Amoxicillin used as Antibiotics.

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