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Prof Aung Tin from Singapore National Eye Centre

Prof Aung Tin

​MBBS, M Med(Ophth), FRCSEd, FRCOphth, FAMS, PhD

Senior Consultant

Specialty: Glaucoma

Sub-specialties: Glaucoma

Conditions Treated by this Doctor:
Glaucoma.

Clinical Appointments

  • Deputy Medical Director (Research) Singapore National Eye CentreSingapore National Eye Centre
  • Senior Consultant Glaucoma Department Singapore National Eye CentreSingapore National Eye Centre

Academic Appointments

  • Academic Vice-Chair (Research) SingHealth Duke-NUS Ophthalmology & Visual Sciences Academic Clinical Programme
  • Professor SingHealth Duke-NUS Ophthalmology & Visual Sciences Academic Clinical Programme
  • Professor, Singhealth Duke-NUS Kwan Im Thong Hood Cho Temple Professorship in Ophthalmology

Profile

 
Professor Aung is a clinician scientist, with clinical practice focusing on glaucoma and research interests in angle closure glaucoma and glaucoma genetics. He was co-Head of the SNEC Glaucoma Department from 2008-2017. With >500 publications, Professor Aung has been awarded >US$20 million in competitive research grant funding. 

He has received numerous awards including The Singhealth Duke-NUS Kwan Im Thong Hood Cho Temple Professorship in Ophthalmology in 2018, The Dr Robert Ritch Award for Excellence & Innovation in Glaucoma 2017, SingHealth Excellence 2016 Awards – Distinguished Visionary Leader Award, NUS University Outstanding Researcher Award 2016, ARVO Fellow Silver Award in 2016, Singapore Translational Research (STaR) Investigator Award in 2014, Alcon Research Institute Award in 2013. De Campo Awards (2013) from the Asia-Pacific Academy of Ophthalmology, President’s Science Award in 2009, the Nakajima Award in 2007 and Singapore National Medical Research Council-Clinician Scientist Awards in 2005 and 2008.

Professor Aung is a member of the Editorial Boards of Ophthalmology, Journal of Glaucoma, Eye, Graefe’s Archive for Clinical and Experimental Ophthalmology, and 6 other journals. He is immediate past President of the World Glaucoma Association and also serves as a Board member of the Asia-Pacific Glaucoma Society and the Asian Angle Closure Glaucoma Club. 

Education

  • PhD (2004)
  • FAMS (2003)
  • FRCOphth (1997)
  • FRCSEd (1997)
  • M Med(Ophth) (1997)
  • MBBS (1990)

Professional Appointments and Committee Memberships

  • Professor, Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore
  • Chair, Organisation Transformation Committee, Singapore National Eye Centre & Singapore Eye Research Institute (2018)
  • President, World Glaucoma Association (2016 – 2017)
  • Member, Academia Ophthalmologica Internationalis (2016 – present)
  • Chairman, National Medical Research Council CS-IRG Local Review Panel (2014 - present)
  • Board of Governors, World Glaucoma Association (2013 - present)
  • Member, Glaucoma Research Society (2009 – present)
  • Board member, Asia-Pacific Glaucoma Society and Asian Angle Closure Glaucoma Club
  • Member, Editorial Boards of Ophthalmology, Journal of Glaucoma, Eye, Graefe’s Archive for Clinical and Experimental Ophthalmology, and 6 other journals
  • Board Member, Asian Angle Closure Glaucoma Club

Awards

  • Singhealth Duke-NUS Kwan Im Thong Hood Cho Temple Professorship in Ophthalmology (2018)
  • Dr Robert Ritch Award for Excellence & Innovation in Glaucoma, The Glaucoma Foundation, USA (2017)
  • Distinguished Visionary Leader Award, SingHealth Excellence Awards (2016)              
  • Outstanding Researcher Award, NUS University Awards (2016)         
  • Silver Award, ARVO Fellow (2016)   
  • Singapore Translational Research (STaR) Investigator Award, National Medical Research Council, Singapore (2014)    
  • Senior Achievement Award, American Academy of Ophthalmology (AAO) (2014)     
  • Alcon Research Institute Award (2013)          
  • De Campo Lecture Award, Asia-Pacific Academy of Ophthalmology (2013)
  • Faculty Outstanding Researcher Award, Yong Loo Lin School of Medicine, National University of Singapore (2012)
  • Achievement Award, Asia-Pacific Academy of Ophthalmology (APAO) (2010)
  • President's Science Award, A-STAR, Singapore (2009)
  • GCEO Excellence Award in Biomedical Research, SingHealth (2009)  
  • Biomedical Research Council Clinician Scientist Award (Senior Category), National Medical Research Council (2008)
  • Distinguished Achievement Award, American Academy of Ophthalmology (AAO) (2008)
  • Nakajima Award and Lecture, Asia-Pacific Academy of Ophthalmology (APAO) (2007)
  • Biomedical Research Council Clinician Scientist Investigator Award (Junior Category), National Medical Research Council (2005)
  • ARVO / Santen Pharmaceutical Travel Fellowship Award, ARVO (2001)          
  • Medical Research Fellowship, National Medical Research Council Singapore Totalisator Board (2000)
  • Grace Ballas Travelling Fellowship, National Medical Research Council, Singapore (1997)

Publications and Research Trials

  1. Jonas JB, Aung T, Bourne RR, Bron AM, Ritch R, Panda-Jonas S. Glaucoma. Lancet. 2017 Nov 11;390(10108):2183-2193. (IF:44.002)

  2. Aung T, Ozaki M, Lee MC, Schlötzer-Schrehardt U, ……… Khor CC. Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci.

  3. Nat Genet. 2017 Jul;49(7):993-1004. (IF: 31.616)

  4. Khor CC, Do T, Jia H, Nakano M, George R, …. Aung T. Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma. Nature Genetics. 2016 May; 48(5):556-62. (IF: 29.352)

  5. Aung T, Ozaki M, Mizoguchi T, Allingham RR, …. Khor CC. A common variant mapping to CACNA1A is associated with susceptibility to Exfoliation syndrome. Nature Genetics 2015; 47(4):387-92. (IF: 29.352)

  6. Chen Y, Lin Y, Vithana EN, Jia L, Zuo X, Wong TY, Chen LJ, Zhu X, Tam POS, Gong B, Qian S, Li Z, Liu X, Mani B, Luo Q, Guzman C, Leung CKS, Li X, Cao W, Yang Q, Tham CCY, ChengY, Zhang X, Wang N, Aung T, Khor CC, Pang CP, Sun X, Yang Z. Common variants near ABCA1 and in PMM2 are associated with primary open-angle glaucoma. Nat Genet 2014; 46(10): 1115-9. (IF:35.532)

  7. Weinreb RN, Aung T, Medeiros FA. The Pathophysiology and Treatment of Glaucoma: A Review.

  8. JAMA. 2014 May 14;311(18):1901-11 (IF: 30.026)

  9. Hysi PG, Cheng CY, Springelkamp H, Macgregor S, ………..Aung T. Genome-wide Analysis of Multiethnic Cohorts Identifies Four New Loci Influencing Susceptibility to Increased Intraocular Pressure and Susceptibility to Glaucoma. Nat Genet- 2014; 46(10): 1126-30 (IF: 29.648)

  10. Nongpiur ME, Khor CC, Jia H, Nair KS, …. Aung T. ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma. PLoS Genet. 2014; 10(3): e1004089. (IF: 8.694)

  11. Vithana EN, Khor CC, Qiao C, Nongpiur ME, ……… Aung T. Genome-wide association analyses identify three new susceptibility loci for Primary Angle Closure Glaucoma. Nat Genetics 2012; 44: 1142-6. (IF:35.532)

  12. Vithana EV, Morgan P, Sundaresan P, Ebenezer N…….., Aung T. Mutations in Na-borate co-transporter SLC4A11 cause recessive Congenital Hereditary Endothelial Dystrophy, CHED2. Nature Genetics, 2006; 38: 755-7 (IF: 24.176)

Research Trials

Grant funded research

  • Singapore Angle Closure Glaucoma Program: characterization, prevention and management (NMRC/ A*STAR) 
  • Enhanced angle closure glaucoma risk assessment system (AGAR+) (NMRC)
  • Eye Surgery and Innovative Technologies (EyeSITe) Programme: stratified medicine for primary angle closure glaucoma (NMRC TCR)
  • The Asia primary tube versus trab (TVT) study (NMRC)
  • Whole exome sequencing to identify actionable mutations causative of primary angle closure glaucoma (NMRC) 
  • Harnessing LOXL1 as a therapeutic candidate for exfoliation syndrome and exfoliation glaucoma (NMRC)
  • Characterizing the role of CACNA1 in exfoliation syndrome and glaucoma (NMRC)
Current Industry Studies
  • A phase III, randomized, observer-masked, active-controlled, parallel-group, multinational and multicentre study assessing the safety and efficacy of DE-117 ophthalmic solution 0.002% compared with latanoprost ophthalmic solution 0.005% in subjects with open-angle glaucoma or ocular hypertension- PEONY study (Santen Pharmaceutical Co., Ltd.)
  • The efficacy and safety of bimatoprost SR in patients Singapore Angle Closure Glaucoma Program: characterization, prevention & management (Allergan Asia Ltd)