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Fever of Unknown Origin / Pyrexia of unknown origin

Fever of Unknown Origin / Pyrexia of unknown origin - How to prevent?

Fever of Unknown Origin / Pyrexia of unknown origin - Causes and Risk Factors

There are many causes of FUO / PUO, ranging from infections to autoimmune diseases to malignancies. Some common causes of FUO / PUO include the following:

Infections such as tuberculosis, human immunodeficiency virus infection, infective endocarditis, undrained abscesses and viral infections.
Autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, temporal arteritis, polymyalgia rheumatica, mixed connective tissue disorders, adult onset Still’s disease, etc.
Hematological malignancies such as lymphoma and leukemia.
Solid organ malignancies such as hepatocellular carcinoma and renal cell carcinoma.
Miscellaneous conditions including drug fever, hypersensitivity syndrome and Kikuchi’s disease

Unfortunately, in 10-20% of cases, the cause of the FUO / PUO remain undiagnosed.

Fever of Unknown Origin / Pyrexia of unknown origin - Preparing for surgery

Fever of Unknown Origin / Pyrexia of unknown origin - Post-surgery care

Fever of Unknown Origin / Pyrexia of unknown origin - Other Information

Human Immunodeficiency Virus (HIV) and Acquired Immune Deficiency Syndrome (AIDS),

Leukaemia (ALL, AML, CLL, CML),

Rheumatoid Arthritis

Article contributed by Infectious Diseases, Singapore General Hospital

The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

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