Full Title: Microenvironment driven re-shaping of pathogenic T effector and regulatory subset in active juvenile idiopathic arthritic patients
Major Category: Research and Disease Areas
Subcategory: Loss of Tolerance
By Leong Jing Yao (Team Lead),
Camillus Chua,
Pavanish Kumar,
Phyllis Chen,
Sharifah Nur Hazirah,
Yeo Joo Guan
We have previously published and identified two dichotomous dysregulated populations within the circulating Teff (CPLs) and Treg (iaTreg) compartments in juvenile idiopathic arthritic patients, that are inflammatory, antigen experienced, correlating with disease activity and exhibiting similar TCR oligoclonality with synovial T cells. Their commonality in immune-phenotype despite being in two functionally distinct compartments, signal the possibility of a common pathogenic origin during active disease manifestation. In this study, we seek to determine the common micro-environment transcriptomic drivers influencing dysregulation in both Teff and Treg compartments during active disease in JIA patients.
