Major Category: Research and Disease Areas
Subcategory: Homeostasis
By Bhairav Paleja (Team Lead),
Ahmad Lajam,
Camillus Chua,
Guo Dianyan,
Lai Liyun,
Nursyuhadah Sutamam,
Sharifah Nur Hazirah
Kidney transplantation significantly improves the survival of end stage renal disease patients. The outcome after kidney transplant have been shown to be affected by race and ethnicity. In the United States, long term allograft survival rates are highest among Asian recipients, followed by Caucasians and lowest for African-Americans. Both, immune and non-immune mediated factors have been accounted for these ethnic discrepancies. African-Americans have been shown to have higher frequencies of lymphocytes and exhibit higher levels of cellular immune response than other ethnic groups. In comparison, Asian recipients show low incidence of acute or chronic rejection but higher rates of death due to infection after kidney transplant. This suggests significant differences in immunological phenotype between Asian and other races. In the current study, we will perform immune profiling of kidney transplant recipients from different racial populations, including Chinese from Singapore and Caucasians/African-Americans from the United States.
