You are invited to attend this seminar hosted by the Institute of Molecular and Cell Biology:
Date: Friday, 16 June 2023
Time: 2.00PM – 3.00PM
Venue: IMCB Seminar Room 03-46, Level 3 Proteos, Biopolis, Singapore 138673 (Physical)
Speaker: A/Prof Eric Fischer
Host: Prof Hong Wanjin
Molecular Mechanisms of Ubiquitin Ligases. From Structure to Therapies
Abstract
Small molecules that induce protein degradation through ligase-mediated ubiquitination, are showing considerable promise as a new pharmacological modality. Following clinical proof of concept by Thalidomide and related IMiDs, several new molecular entities are entering clinical development. Significant progress has been made towards chemically induced targeted protein degradation using heterobifunctional small molecule ligands and exciting opportunities arise from better understanding molecular glues. I will present recent work towards a better understanding of the molecular principles that govern neo-substrate recruitment by small molecule degraders.
Biography
Eric Fischer, Ph.D. is an Independent Investigator and the Director of the Chemical Biology Program at Dana-Farber Cancer Institute, Associate Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School, and Co-Director of the DFCI Center for Protein Degradation. Dr. Fischer trained in structural biology and biochemistry at the University of Basel and conducted his doctorate studies at the Friedrich Miescher Institute for Biomedical Research. During his graduate work, he has been recognized for pioneering work on the mechanism of action of thalidomide. Since moving to Boston, his lab focuses on the understanding of fundamental processes in ubiquitin signaling, and the molecular basis of ubiquitin ligase activity, targeting and regulation. His lab seeks to leverage this understanding for the development of novel therapeutic approaches, such as targeted protein degradation. He and his lab have significantly contributed to our understanding of small molecule mediated protein degradation, and its widespread application in academia and industry. Dr. Fischer has co-founded Civetta Therapeutics, Proximity Therapeutics and Neomorph and serves on the scientific advisory board for the Institute for Protein Innovation, Avilar Therapeutics and Photys Therapeutics.
ALL ARE WELCOME (No registration required)
For upcoming seminars in IMCB, please visit https://www.a-star.edu.sg/imcb