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Bosentan

Drug Class: Commonly Known As: Category:
Endothelin Receptor Antagonist Tracleer

Bosentan - What is it for

Bosentan is used to treat pulmonary arterial hypertension. Every individual may respond to treatment in different ways. It is important that patients have realistic expectations of what the treatment can do.

It lowers the pressure in the pulmonary arteries (the blood vessels that transfer oxygen from the lungs to the blood) by blocking the effects of endothelin. It may have the potential to reverse some of the damage done by the condition. This should also improve symptoms such as breathlessness and increase your ability to exercise.

Bosentan - Side Effects, Precautions, and Contraindications

What side effects can Bosentan cause?

  • Bosentan may cause changes in liver enzymes. Although these are not usually significant, you will need frequent blood tests (monthly) to monitor your liver function. Inform your Cardiologist, Nurse and/or Pharmacist if you have signs of liver problems like dark urine, increased tiredness, loss of appetite, light- coloured stools, vomiting, yellow skin or eyes.
  • Bosentan may cause flushing, low blood pressure, fainting or headache. These effects are minimized by starting with a lower dose and may improve or go away with time. To reduce giddiness when changing position, rise slowly from a sitting or lying position.
  • Bosentan may cause anaemia (low haemoglobin level). Regular blood tests (full blood counts) will be scheduled to monitor this.
  • Bosentan may cause leg oedema (swelling). Inform your Cardiologist, Nurse or Pharmacist if you experience this.

Before taking Bosentan, what precautions must I follow?

Please inform your doctor if you are pregnant before starting this medicine.

What food or medicine must I avoid when I take Bosentan?

  • Patients taking Bosentan should not take Glibenclamide/Glyburide (a medication for diabetes) or Cyclosporine (a medication for suppression of the immune system) due to increased risk of side effects.
  • Bosentan may interact with certain antibiotics and antifungal medications taken by mouth. Please consult the Pulmonary Hypertension team if you are started on any of these.
  • Inform your Cardiologist, Nurse and/or Pharmacist if you are taking any other over-the- counter (OTC) medications, health/herbal supplements or traditional medications. The Pulmonary Hypertension Team will check to ensure that the combination of medications you are taking is safe.
  • Avoid grapefruit juice while on this medication.

Bosentan - Dosage and How to Use

How should Bosentan be used?

Bosentan is to be taken by mouth twice a day.

Bosentan is initially started at a lower dose. Your condition will be monitored closely. Your Cardiologist may later adjust your dosage to better control your condition. You may take Bosentan with or without food.

As this medication may cause birth defects, female patients of childbearing age should take precautions by using at least 2 reliable methods of contraception to avoid pregnancy. If you suspect you may be pregnant, inform your Cardiologist as soon as possible.

What should I do if I miss a dose?

If you forget to take a dose, take it as soon as you remember but do not take two doses at once.

What should I do if I overdose?

Bosentan - Handling and Storage

How should I handle Bosentan safely?

How should I store Bosentan?

Keep away from children;#Keep in a cool, dry place, away from direct sunlight;#

How should I dispose of Bosentan safely?

Bosentan - Additional Information

Do not stop taking this drug suddenly without informing your Cardiologist, Nurse and/or Pharmacist as it may make your condition worse.

  • Updated on
  • This article is contributed by Department of Pharmacy National Heart Centre Singapore

    The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

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