What is Nasopharyngeal Cancer?
The area behind the nose and just above the back of the throat is called the nasopharynx. The cells lining the nasopharynx can become cancerous and give rise to nasopharyngeal cancer or NPC.
How common is Nasopharyngeal Cancer?
Nasopharyngeal cancer remains at the eighth position in most common cancer among Singaporean men. It affects men more frequently than women and it occurs between the ages of 35 to 55 years. This type of cancer is more frequently seen among the Chinese(especially Cantonese). It is not as common in USA or Europe.
Symptoms and Signs of Nasopharyngeal Cancer
A painless lump in the neck is found in nearly 75% of newly diagnosed nasopharyngeal cancer. A doctor should be seen if any of the following symptoms develop and persist: a painless lump in the neck, excessive nose discharge or blockage or bleeding, decreased hearing or ringing in the ears, or unusual face pain or numbness, double vision or headache. As cancer can spread to any organ or tissue in the body, in the late stages there may be symptoms from the lung, bone or liver.
If nasopharyngeal cancer is suspected, a doctor will look for swelling or lumps in the neck. The doctor may examine the nasopharynx with a special angled mirror that is placed at the back of the throat or pass a flexible tube called a nasoscope (usually 5 - 6 mm in diasmeter) into one of the nostrils and to the back of the nose to look for lumps or ulcers. Small pieces of tissues may be removed during this examination to diagnose cancer. This is called biopsy.
If there is a neck lump, small pieces of the lump can be removed using a needle and syringe under local anaesthesia. The tissue is then examined under a mircoscope to look for cancer cells.
Once cancer is confirmed, further tests will be done to see if the cancer has spread from the nasopharynx to other parts of the body. The tests usually include a thorough physical examination, blood tests, chest x-rays and scans of the head and neck region. A bone scan and liver scan may also be ordered to see if the cancer is suspected to have spread to these areas.
Treatment of Nasopharyngeal Cancer
Early nasopharyngeal cancer is treated by radiotherapy. A team led by a radiation oncologist, a doctor who specializes in giving radiotherapy, plan radiation therapy. Radiation is given to an area that covers the region around the nasopharynx and the neck and down to the collarbone. Temporary side effects include redness and peeling of the skin of the neck and cheek area, dryness of the mouth, mouth ulcers and loss of appetite.
Chemotherapy is sometimes used as part of the treatment. Chemotherapy uses drugs that kills cancers when it has spread to other parts of the body such as lungs, liver, and bones. The drugs are injected into the hand veins.
Chemotherapy may also be used in combination with radiotherapy to improve the efficiency of radiotherapy. Due to the location of the cancer, surgery is not commonly used. In some patients, surgery may be used to remove lumps in the neck that have persisted or returned after treatment with radiotherapy.
Surgery may also be considered when the cancer in the nasopharynx recurs despite radiotherapy and there is no spread of cancer elsewhere in the body.
Prognosis of Nasopharyngeal Cancer
Clinical examinations, x-rays and pathology reports all help the medical team decide what the progress of an individual case of Nasopharyngeal Cancer may be. Then, the appropriate course of treatment will be put into action. The treatment strategy will vary from person to person. With prompt and appropriate treatment, the outlook for a person with Nasopharyngeal Cancer is reasonable. Early disease limited to nasopharyngeal can be cured with radiation in large majority.
I have several relatives with nasopharyngeal cancer. None of them smoke. Why did they get it?
Nasopharyngeal cancer is not directly associated with smoking. It may be a virus-related cancer and therefore found in members of a close community or family but is not contagious. Although not proven to be hereditary, nasopharynx cancer is known to be present in several members of one family.
I have a painless neck lump. It did not get better after antibiotics. What should I do next?
Painless neck lumps may be due to infection of the mouth and throat area or it may be a benign lump. It is best to seek medical attention in case it is cancerous. If there are no obvious reasons for the neck lump such as throat infection or tuberculosis, surgical removal of the lump and sending it for further testing may be necessary.
National Cancer Institute www.cancer.gov/cancertopics/types/lung
Cancer Therapies www.cancer.gov/Targeted
American Cancer Society www.cancer.org/cancer/index
American Cancer Society www.cancer.org
Cancer Information Service (National Cancer Institute, USA) www.nci.nih.gov
Click here for English publication on Nasopharyngeal Cancer
Click here for Chinese publication on Nasopharyngeal Cancer
For further enquiries on nasopharynx cancer, please call the Cancer Helpline at (65) 6225 5655 or email to firstname.lastname@example.org.
Need indepth information ?
Access our Conditions & Treatments sections for related topics on Head and Neck Cancer, Head and Neck Surgery, Lung Cancer and Neck Pain.
The medical institutions within SingHealth that offer consultation and treatment for this condition include:
Joint Commission International
- Singapore General Hospital
- KK Women's and Children's Hospital
- National Cancer Centre Singapore
- National Dental Centre Singapore
- National Heart Centre Singapore
- Singapore National Eye Centre
- SingHealth Polyclinics
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