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Wee Tien Seng Joseph
Dr Wee Tien Seng Joseph
National Cancer Centre Singapore
Division of Radiation Oncology
Senior Consultant
MBBS, FRCR (Clinical Oncology)(UK)

Dr Wee is a Senior Consultant at the Division of Radiation Oncology

He subspecialises in Head and Neck Oncology with special interests in Nasopharyngeal Carcinoma (NPC).

He was awarded the National Medical Research Council Clinician Scientist Award (Senior Investigator), from 2009-2013. He started the Intensity Modulated Radiation Therapy (IMRT) program for NPC in Singapore in 2002. He was also the Principal Investigator for 2 Randomised Phase 3 trials for NPC. He sits on the Editorial Board of several Oncology journals.


·         MBBS (Singapore) 1983

·         FRCR (UK) 1991

·         FAMS (Singapore) 1995

·         Grad Dip in Acupuncture 2008

·         Advanced Speciality Training Certificate in Therapeutic Radiology (Singapore) 1994

·         Completion of Specialist Training - Accreditation (The Royal College of Radiologists) 1995

·         Certificate of Specialist Accreditation (Therapeutic Radiology) - Ministry of Health, Singapore 1998

Professional Appointments and Committee Memberships

President, Singapore Society of Oncology 2000 - 2002
Member, 36th Council, Singapore Cancer Society 2000 - 2001
Hon Auditor, Singapore Society of Oncology 2002
Hon Secretary, Chapter of Radiologists Academy of Medicine, Singapore 1996 - 1998
Hon Auditor, Singapore Radiological Society 1997
Hon Treasurer, Singapore Radiological Society 1996
Hon Treasurer, Singapore Society of Oncology 1994 - 1995
Member, Medical Advisory Sub-committee Breast Cancer Foundation, Singapore 1998 – Present
Hon Treasurer, Medical Society / Medical Club
National University of Singapore 
1979 - 1980
Secretary, Organising Committee
6th Advanced Course in Head & Neck Cancer Surgery
S’pore Assoc of Head & Neck Surgeons / Academy of Medicine
1997 - 1998
Member, Organising Committee, 7th Annual Scientific Meeting,
S’pore Radiological Society / Academy of Medicine
Member, Facilities Subcommittee, 9th Annual Scientific Meeting,
Singapore General Hospital
Chairman, Organising Committee, 5th Annual Scientific Meeting,
S’pore Radiological Society / Academy of Medicine 
National Cancer Centre  
Member, Executive Committee 2001
Member, Medical Board 2007
Member, Research Comittee 2001
Co-Chairman, Disease Outbreak Response System Task Force 2006 - 2009
Chairman, JCI Steering Committee 2008 - 2010
Member, Quality Assurance Committee 2007
Member, Singhealth Research Committee 2001 - 2002
Infection Control Officer, SARS Task Force 2003
Programme Leader, Nasopharyngeal Cancer
Cancer Service Line Development Programme
2004 - 2006
Chairman, NPC Tumour Specific Workgroup 2002
Member, Clinical Trials Steering Committee 2000 - 2005
Leader, National Medical Research Council / National Cancer Centre Delegation to Hong Kong to discuss Nasopharyngeal Cancer Trails in Asia-Pacific Hong Kong, SAR  2000
Member, National Medical Research Council Delegation to Trans-Tasman  Radiation Oncology Group Newcastle, Australia  1999
Member, Singapore General Hospital Delegation to
6th UCSF-Stanford – SGH Joint Update, San Francisco 
Member, National Medical Research Council Delegation to University of Udayana, Bali, Indonesia Site inspection for NMRC Trials  1998
Member, Advisory Panel Cancer Helpline  
Member, Media Committee  
Vice Chairman and Secretary Nasopharyngeal Cancer Workgroup  1997 - present

 - Head & Neck Cancer Subcommittee
 - Lung Cancer Subcommittee
 - Upper Gastrointestinal Cancer Subcommittee

1997 - present
Member, Electronic Medical Records Workgroup, Singapore General Hospital  1997 - 1998
Departmental Representative,  DRG Committee, Singapore General Hospital  1998 - 2000
Community Work  
Volunteer Night Duty Doctor,  St Andrew’s Community Hospital    1992 - 1997

  • National Medical Research Council, Clinician Scientist Award (Senior Investigator) 2009 - 2013

  • Singapore Radiological Society and College of Radiologists, Singapore : 4th FY Khoo Lecturer 2008

  • Singapore Armed Forces National Service Medal 2000

  • Singapore General Hospital Service with a Heart Award Oct 1997

  • Singapore Armed Forces Good Service Medal 1997

  • Public Services Commission - Health Manpower Development Plan Scholarship for a fellowship in Clinical Oncology at The Middlesex Hospital, London 1989 - 1991

  • Local Merit Bursary (Public Services Commission) to study Medicine at the National University of Singapore 1978 - 1983

Publications and Research Trials
  • Sim CP, Wee J, Xu Y et al. Anti-caries effect of CPP-ACP in irradiated nasopharyngeal carcinoma patients. Clin Oral Investig. 2014 Sep 27. [Epub ahead of print].


  • Quoted in: EBV in Asia: Nasopharyngeal carcinoma – pg 99. In: Crawford DH, Rickinson A (Eds). Cancer Virus – The Story of Epstein-Barr Virus. Oxford, Oxford University Press, 2014


  • Sun Y, Yu XL, Luo W, Lee AW, Wee JT, Lee N et al. Recommendation for a contouring method and atlas of organs at risk in nasopharyngeal carcinoma patients receiving intensity-modulated radiotherapy. Radiother Oncol. 2014 Mar;110(3):390-7. (JIF 4.857)


  • Wee J, Tan EH, Tai BC et al. Randomized trial of radiotherapy versus concurrent chemo-radiotherapy followed by adjuvant chemotherapy in patients with AJCC Stage III and IV nasopharyngeal cancer of the endemic variety. In: Shah JP ed.  A Century of Progress in Head and Neck Cancer. Philadelphia, Jaypee Brothers Medical Publishers, 2014


  • Tham I, Cheah SL, Soong YL, Wee J. Commentary: Retrospective Analysis of 5037 patients with nasopharyngeal carcinoma treated during 1976-1985: overall survival and patterns of failure.  In: Shah JP ed.  A Century of Progress in Head and Neck Cancer. Philadelphia, Jaypee Brothers Medical Publishers, 2014


  • Yom S and Wee J. 14.ASK THE EXPERTS: Maximizing the therapeutic ratio in the treatment of nasopharyngeal carcinoma. In: Yom S and Wee J ed. Clinical Insights: Nasopharyngeal Carcinoma – Management Strategies. (eBook) London, Future Medicine, 2014.


·         Yom S and Wee J ed. Clinical Insights: Nasopharyngeal Carcinoma – Management Strategies. (eBook) London, Future Medicine, 2014


  • Toh HC, Ha TC, Wee J. Invited Commentary: Personalized Medicine in Nasopharyngeal Cancer. Lancet Oncol 2012 May 2. [Epub ahead of print] (JIF 22.59)


  • J Wee. Invited Commentary: Nasopharyngeal Carcinoma – a promising future. Lancet Oncol 2012 Feb;13(2):116-8. Epub 2011 Dec 15 (JIF 22.59)


  • Hai-Yun Wang, Bing-Yu Sun, Zhi-Hua Zhu…. Wee J.. et al. An Eight-signature Classifier for Prediction of Nasopharnyngeal Carcinoma Survival. J Clin Oncol. 2011 Dec 1;29(34):4516-25. Epub 2011 Oct 24. (JIF 18.97)


  • Tham IW, Lin S, Pan J,.. Wee J. Intensity-Modulated Radiation Therapy Without Concurrent Chemotherapy for Stage IIB Nasopharyngeal Cancer. Am J Clin Oncol. 2010 Jun;33(3):294-9 (JIF 1.768)


  • Gao F, Wee J, Wong HB, Machin D. Quality-of-Life-Adjusted Survival Analysis of Concurrent Chemo Radiotherapy for Locally Advanced (Nonmetastatic) Nasopharyngeal Cancer. Int J Radiat Oncol Biol Phys. 2010 Oct 1;78(2):454-60. Epub 2010 Jan 21 (JIF 4.503)


  • Wee JT, Anderson BO, Corry J, et al. Management of the neck after chemoradiotherapy for head and neck cancers in Asia: consensus statement from the Asian Oncology Summit 2009   Lancet Oncol. 2009 Nov;10(11):1086-92 (JIF 14.470)


·         Wee J. Concurrent Chemotherapy-Enhanced Radiation: Trials and Conclusions. In: Lu, Jiade J.; Cooper, Jay S.; Lee, Anne W. M. (Eds.). Nasopharyngeal Cancer. Multidisciplinary Management. Heidelberg, Springer, 2009


  • Tham IW, Hee SW, …., Wee JT. Treatment of Nasopharyngeal Carcinoma Using Intensity-Modulated Radiotherapy-The National Cancer Centre Singapore Experience. Int J Radiat Oncol Biol Phys. 2009 Dec 1;75(5):1481-6. Epub 2009 Apr 20


·         Tham WK, Yap SP…. Wee J. Retropharyngeal nodal metastasis related to higher rate of distant metastasis in patients with N0 and N1 nasopharyngeal cancer. Head Neck 2009 Apr;31(4):468-74


  • Chua ML, Ong SC, Wee J et al. Comparison of four modalities for distant metastasis staging in endemic nasopharyngeal carcinoma. Head Neck, Mar;31(3):346-54.


·         Wee J. 4th FY Khoo Memorial Lecture 2008: Nasopharyngeal Cancer Workgroup - The Past, The Present and The Future. Ann Acad Med Singapore. 2008 Jul; 37(7): 606-9


  • J Wee, EH Tan. Nasopharyngeal Cancer. In: Gospodarowicz MK, ed. Prognostic Factors in Cancer. 3rd Ed. New Jersey: John Wiley & Sons, 2006. 


  • Low WK, Toh ST, J Wee et al. Sensori-neural hearing loss after radiotherapy and chemo-radiotherapy: a single blinded randomised study. J Clin Oncol. 2006. Apr 20; 24(12): 1904-9.


  • Tan EH, Leong SS…..J Wee. Multimodality management of nasopharyngeal carcinoma. In: Adelstein DJ ed. Current Clinical Oncology: Squamous Cell Head and Neck Cancer. New Jersey, Humana Press Inc, 2005.


  • Soo KC, Tan EH, J Wee et al. Surgery and adjuvant radiotherapy vs concurrent chemoradiotherapy in stage III/IV nonmetastatic squamous cell head and neck cancer: a randomised comparison. Br J Cancer. 2005 Aug 8;93(3):279-86.


·         J Wee, Tan EH, Tai BC, et al. Randomized Trial of Radiotherapy versus Concurrent Chemo-Radiotherapy followed by Adjuvant Chemotherapy in Patients with AJCC/UICC (1997) Stage III and IV Nasopharyngeal Cancer of the Endemic Variety. J Clin Oncol. 2005 Sep 20;23(27):6730-8

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