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Tan Hiang Khoon
Dr Tan Hiang Khoon
National Cancer Centre Singapore
Division of Surgical Oncology
Senior Consultant
MBBS (S’pore), FRCSEd, FAMS, PhD
Dr Tan Hiang Khoon is a senior consultant at the National Cancer Centre Singapore, a Chairman, Division of Surgery at Singapore General Hospital and also Senior Consultant, SingHealth Duke-NUS Head & Neck Centre.

Dr Tan received his medical degree from the National University Singapore School of Medicine in 1991. He received his specialist training in the Department of General Surgery at the Singapore General Hospital.

He joined the Head and Neck Service at National Cancer Center Singapore in 2005 and subsequently underwent his Advanced Training in Head and Neck Surgical Oncology in Institute Gustave Roussy, Paris. He is one of the pioneers in the development of endoscopic and robotic Head and Neck surgery in Singapore.

His research interests are in head and neck squamous cell carcinoma and the use of cancer biomarkers in clinical algorithms. His work in methylation profiling of resection margins was awarded the Best Early Detection Paper in the 7th International Conference on Head and Neck Cancer.
  Dr Tan was also awarded the Singapore National Youth Award for his role as the founding chairman of Children’s Cancer Foundation (Singapore). He is currently the Academic Vice Chair (Research) for ACP Surgery and Director of Community Outreach and Philanthropy in National Cancer Center Singapore.
Professional Appointments and Committee Memberships

·         Member, FAMS

·         Instructor, ATLS


·         Wong Hock Boon Society Outstanding Research Mentor 2013

·         Service with a Heart Award, 2012

·         Duke-NUS Graduate Medical School Singapore

·         Faculty Appreciation Award 2011 for Most Knowledgeable Faculty, 2011

·         Service Quality Partners Award for outstanding service and distinguished service champion, 2009

·         Best Early Detection and Prevention Paper, 7th International conference on Head and Neck Cancer, San Francisco, 2008

·         HMDP Fellowship; Head and Neck Surgical Oncology 2006 – 2008

·         Best Poster Award – 14th Annual Scientific Meeting, 2003

·         NMRC Research Fellowship for Ph.D. Programme, 1999-2002

·         Asia Award for Excellence in Youth Work, 1999.

·         Regional award conferred by Commonwealth Youth Project Asian Centre, 1999.

·         Singapore Youth Award (Community and Youth Service category)1998.

·    The Award confers national honour and recognition upon Singaporean youth who have made significant achievements and contribution to the society, 1998.

Publications and Research Trials

·         Management of orocutaneous fistuals using a vacuum-assisted closure systems. Tian B, Khoo D, Tay AC, Soo KC, Tan NC, Tan HK, Iyer NG. Head Neck. 2013 Jun 4


·      Outcomes and Prognostic Factors of Post-irradiation and de novo Sarcomas of the Head and Neck: A Histologically Matched Case-Control Study. Yeang MS, Tay K, Ong WS, Thiagarajan A, Tan DS, Ha TC, Teo PT, Soo KC, Tan HK, Iyer NG. Ann Surg Oncol. 2013 Sep;20(9):3066-75

·         Squamous cell carcinoma of the ear arising in patients after radiotherapy for nasopharyngeal  carcinoma. Tay G, Tan HK, Thiagarajan A, Soo KC, Iyer NG. Eur Arch Otorhinolaryngol. 2013 Apr 16


·         Prognostic Significance of Invasion Depth in Oral Tongue Squamous Cell Carcinoma.  Tan WJ, Chia CS, Tan HK, Soo KC, Iyer NG. ORL J Otorhinolaryngol Relat Spec. 2012;74(5):264-70

·         Reversible recurrent laryngeal nerve palsy in acute thyroiditis. Chang M, Khoo JB, Tan HK.


·         Singapore Med J. 2012 May;53(5):e101-3


·         Acute marjolin’s ulcer: a forgotten entity. Soh LJ, Tan HK. Ann Acad Med Singapore. 2013 Mar;42(3):153-4.


·         Management and outcome of head and neck squamous cell carcinomas in obese patients.


·         Deneuve S, Tan HK, Eghiaian A, Temam S. Oral Oncol. 2011 Jul;47(7):631-5.

·         Outcomes of oral tongue cancer: does age matter?  Yip CS, Charn TC, Wee JT, Tan TW, Goh C, Tan HK, Fong KW. Ann Acad Med Singapore. 2010 Dec;39(12):897-7


·         Salvage surgery after concomitant chemoradiation in head and neck squamous cell carcinomas - Stratification for post-salvage survival. Tan HK, Giger R, Auperin A, Bourhis J, Janot F, Temam S. Head Neck. 2010 Feb;32(2):139-47.


·         Quantitative methylation analyses of resection margins predict local recurrences and disease specific deaths in patients with head and neck squamous cell carcinomas.  Tan HK, Saulnier P, Auperin A, Lacroix L, Casiraghi O, Janot F, Fouret P, Temam S. Br J Cancer. 2008 Jul 22;99(2):357-63.


·         Amplification and overexpression of PPFIA1, a putative 11q13 invasion suppressor gene, in head and neck squamous cell carcinoma. Tan KD, Zhu Y, Tan HK, Rajasegaran V, Aggarwal A, Wu J, Wu HY, Hwang J, Lim DT, Soo KC, Tan P. Genes Chromosomes Cancer. 2008 Apr;47(4):353-62.


·         The musculo-mucosal facial artery flap: harvesting technique and indications. Ayad T, Kolb F, De Monès E, Mamelle G, Tan HK, Temam S. Ann Chir Plast Esthet. 2008 Dec;53(6):487-94.


·         Acute variceal bleed in a patient with idiopathic myelofibrosis successfully treated with endoscopic variceal band ligation. Goh BK, Chen JJ, Tan HK, Yong WS, Chan WH. Dig Dis Sci. 2007 Jan;52(1):173-5.


·         Epidural emphysema associated with spontaneous pneumomediastinum. Goh BK, Tan HK, Tan FL, Koong HN. Am J Surg. 2006 Sep;192(3):355-6.


·         Double pylorus. Goh BK, Tan HK. Am J Surg. 2006 Apr;191(4):515-6.


·         Healthcare worker seroconversion in SARS outbreak. Chow PK, Ooi EE, Tan HK, Ong KW, Sil BK, Teo M, Ng T, Soo KC. Emerg Infect Dis. 2004 Feb;10(2):249-50.


·         Tissue inhibitor of metalloproteinase 1 inhibits excitotoxic cell death in neurons. Tan HK, Heywood D, Ralph GS, Bienemann A, Baker AH, Uney JB. Mol Cell Neurosci. 2003 Jan;22(1):98-106.


·         Disruption of the GluR2-NSF interaction protects primary hippocampal neurons from ischemic stress. Ralph GS, Bienemann A, Ma J, Tan HK, Noel J, Henley JM, Uney JB. Mol Cell Neurosci. 2001 Apr;17(4):662-70.


·         Spectrum of roller-blading injuries. Goh SH, Tan HK, Yong WS, Low BY. Ann Acad Med Singapore. 1996 Jul;25(4):547-9

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