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Tan Puay Hoon
Prof Tan Puay Hoon
Singapore General Hospital
Chairman, Division of Pathology & Senior Consultant

Dr Tan Puay Hoon is Senior Consultant Histopathologist and Chairman, Division of Pathology, Singapore General Hospital, Singapore. She has active interests in breast, urologic and renal pathology, and was a Volume Editor of the 2012 WHO Classification of Tumours of the Breast.  She sits on the Editorial Boards of Modern Pathology, Breast Cancer Research, Journal of Clinical Pathology, Pathology, Seminars in Diagnostic Pathology, and Analytical and Quantitative Cytology and Histology. She is Associate Editor of Histopathology and the Singapore Medical Journal. Apart from a busy service largely focused on subspecialty surgical signouts, she and her collaborators are recipients of several research grants related to translational studies of breast and prostate cancer. She is author of more than 400 publications, and participates regularly in regional and international meetings.

Dr Tan’s research interests in breast pathology centre around the classification of breast fibroepithelial lesions and their molecular pathogenesis, triple negative breast cancers, and ductal carcinoma in situ. In urologic pathology, she is engaged in prostate and renal cancer studies and is a contributor to the 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs.

She is the immediate Past-President of the International Society of Breast Pathology, and was Councillor for Asia of the International Society of Urological Pathology (2009 – 2015).

  • MBBS (National University of Singapore, 1986)
  • FRCPA (Royal College of Pathologists of Australasia, 1994)
  • FAMS (Academy of Medicine, Singapore, 1996)
  • MD (National University of Singapore, 2002)
  • FRCPath (Royal College of Pathologists, United Kingdom, 2005)
  • MIAC (International Academy of Cytology, 2005)
Professional Appointments and Committee Memberships
  • Chairman, Division of Pathology, Singapore General Hospital, 1 Jun 2016 – current
  • Academic Chair, Pathology Academic Clinical Programme, 1 Apr 2013 – current
  • Professor, Duke-NUS Medical School, 1 Apr 2014 – current
  • Professor, Departments of Anatomy and Pathology, Yong Loo Lin School of Medicine, National University of Singapore, 1 Apr 2014 – current
  • 2015 National Outstanding Clinician Award, National Medical Excellence Awards (Ministry of Health Singapore)
  • 2015 SingHealth GCEO Outstanding Clinician Award
  • 2015 The Long Service Medal 2015 (MOH), National Day Awards
  • 2015 Singapore Society of Pathology - Becton Dickinson (BD) Award in Pathology 2015
Publications and Research Trials
  1. Lim SZ, Selvarajan S, Thike AA, Nasir ND, Tan BK, Ong KW, Tan PH. Breast sarcomas and malignant phyllodes tumours: comparison of clinicopathological features, treatment strategies, prognostic factors and outcomes. Breast Cancer Res Treat. 2016 Sep;159(2):229-44. doi: 10.1007/s10549-016-3946-1. Epub 2016 Aug 19. PubMed PMID: 27541020. JIF (2015): 4.085
  2. Kweldam CF, Nieboer D, Algaba F, Amin MB, Berney DM, Billis A, Bostwick DG, Bubendorf L, Cheng L, Compérat E, Delahunt B, Egevad L, Evans AJ, Hansel DE, Humphrey PA, Kristiansen G, van der Kwast TH, Magi-Galluzzi C, Montironi R, Netto GJ, Samaratunga H, Srigley JR, Tan PH, Varma M, Zhou M, van Leenders GJ. Gleason grade 4 prostate adenocarcinoma patterns: an interobserver agreement study among genitourinary pathologists. Histopathology. 2016 Sep;69(3):441-9. doi: 10.1111/his.12976. Epub 2016 May 24. PubMed PMID: 27028587. JIF (2015): 3.425
  3. Cheng CL, Azhar R, Sng SH, Chua YQ, Hwang JS, Chin JP, Seah WK, Loke JC, Ang RH, Tan PH. Enabling digital pathology in the diagnostic setting: navigating through the implementation journey in an academic medical centre. J Clin Pathol. 2016 Sep;69(9):784-92. doi: 10.1136/jclinpath-2015-203600. Epub 2016 Feb 12. PubMed PMID: 26873939. JIF (2015): 2.912
  4. Chng TW, Lee JY, Lee CS, Li H, Tan MH, Tan PH. Validation of the Singapore nomogram for outcome prediction in breast phyllodes tumours: an Australian cohort. J Clin Pathol. 2016 Jul 27. pii: jclinpath-2016-203951. doi: 10.1136/jclinpath-2016-203951. [Epub ahead of print] PubMed PMID: 27466383. JIF (2015): 2.912 
  5. Tan BY, Thike AA, Ellis IO, Tan PH. Clinicopathologic Characteristics of Solid Papillary Carcinoma of the Breast. Am J Surg Pathol. 2016 Jul 19. [Epub ahead of print] PubMed PMID: 27438988. JIF (2015): 4.951
  6. Lim SZ, Ong KW, Tan BK, Selvarajan S, Tan PH. Sarcoma of the breast: an update on a rare entity. J Clin Pathol. 2016 May;69(5):373-81. doi: 10.1136/jclinpath-2015-203545. Epub 2016 Jan 4. Review. PubMed PMID: 26729013. JIF (2015): 2.912 
  7. Tan WJ, Chan JY, Thike AA, Lim JC, Md Nasir ND, Tan JS, Koh VC, Lim WK, Tan J, Ng CC, Rajasegaran V, Nagarajan S, Bay BH, Teh BT, Tan PH. MED12 protein expression in breast fibroepithelial lesions: correlation with mutation status and oestrogen receptor expression. J Clin Pathol. 2016 Apr 7. pii: jclinpath-2015-203590. doi: 10.1136/jclinpath-2015-203590. [Epub ahead of print]  PubMed PMID: 27056456. JIF (2015): 2.912
  8. Matsumoto H, Thike AA, Li H, Yeong J, Koo SL, Dent RA, Tan PH, Iqbal J. Increased CD4 and CD8-positive T cell infiltrate signifies good prognosis in a subset of triple-negative breast cancer. Breast Cancer Res Treat. 2016 Apr;156(2):237-47. doi: 10.1007/s10549-016-3743-x. Epub 2016 Mar 9. PubMed PMID:  26960711. JIF (2015): 4.085
  9. Tan WJ, Cima I, Choudhury Y, Wei X, Lim JC, Thike AA, Tan MH, Tan PH. A five-gene reverse transcription-PCR assay for pre-operative classification of breast fibroepithelial lesions. Breast Cancer Res. 2016 Mar 9;18(1):31. doi: 10.1186/s13058-016-0692-6. PubMed PMID: 26961242; PubMed Central PMCID: PMC4784364. JIF (2015): 5.211
  10. Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH. Phyllodes tumours of the breast: a  consensus review. Histopathology. 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. Review. PubMed PMID: 26768026. JIF (2015): 3.425
  11. Rakha EA, Badve S, Eusebi V, Reis-Filho JS, Fox SB, Dabbs DJ, Decker T, Hodi Z, Ichihara S, Lee AH, Palacios J, Richardson AL, Vincent-Salomon A, Schmitt FC, Tan PH, Tse GM, Ellis IO. Breast lesions of uncertain malignant nature and limited metastatic potential: proposals to improve their recognition and clinical management. Histopathology. 2016 Jan;68(1):45-56. doi: 10.1111/his.12861. Review. PubMed PMID: 26348644. JIF (2015): 3.425
  12. Tan J, Ong CK, Lim WK, Ng CC, Thike AA, Ng LM, Rajasegaran V, Myint SS, Nagarajan S, Thangaraju S, Dey S, Nasir ND, Wijaya GC, Lim JQ, Huang D, Li Z, Wong BH, Chan JY, McPherson JR, Cutcutache I, Poore G, Tay ST, Tan WJ, Putti TC,  Ahmad BS, Iau P, Chan CW, Tang AP, Yong WS, Madhukumar P, Ho GH, Tan VK, Wong CY, Hartman M, Ong KW, Tan BK, Rozen SG, Tan P, Tan PH, Teh BT. Genomic landscapes of breast fibroepithelial tumors. Nat Genet. 2015 Nov;47(11):1341-5. doi: 10.1038/ng.3409. Epub 2015 Oct 5. PubMed PMID: 26437033. JIF (2015): 31.616
  13. Koh VC, Lim JC, Thike AA, Cheok PY, Thu MM, Tan VK, Tan BK, Ong KW, Ho GH, Tan WJ, Tan Y, Salahuddin AS, Busmanis I, Chong AP, Iqbal J, Thilagaratnam S, Wong JS, Tan PH. Characteristics and behaviour of screen-detected ductal carcinoma in  situ of the breast: comparison with symptomatic patients. Breast Cancer Res Treat. 2015 Jul;152(2):293-304. doi: 10.1007/s10549-015-3472-6. Epub 2015 Jun 16. PubMed PMID: 26077641. JIF (2015): 4.085
  14. Tan PH, Schnitt SJ, van de Vijver MJ, Ellis IO, Lakhani SR. Papillary and neuroendocrine breast lesions: the WHO stance. Histopathology. 2015 May;66(6):761-70. doi: 10.1111/his.12463. Epub 2015 Jan 23. PubMed PMID: 24845113. JIF (2015): 3.425
  15. Tan WJ, Thike AA, Tan SY, Tse GM, Tan MH, Bay BH, Tan PH. CD117 expression in breast phyllodes tumors correlates with adverse pathologic parameters and reduced survival. Mod Pathol. 2015 Mar;28(3):352-8. doi: 10.1038/modpathol.2014.111. Epub 2014 Sep 12. PubMed PMID: 25216225. JIF (2015): 5.485
  16. Rakha EA, Tan PH, Varga Z, Tse GM, Shaaban AM, Climent F, van Deurzen CH, Purnell D, Dodwell D, Chan T, Ellis IO. Prognostic factors in metaplastic carcinoma of the breast: a multi-institutional study. Br J Cancer. 2015 Jan 20;112(2):283-9. doi: 10.1038/bjc.2014.592. Epub 2014 Nov 25. PubMed PMID: 25422911; PubMed Central PMCID: PMC4453452. JIF (2015): 5.569
  17. Choudhury Y, Wei X, Chu YH, Ng LG, Tan HS, Koh V, Thike AA, Poon E, Ng QS, Toh CK, Kanesvaran R, Tan PH, Tan MH. A multigene assay identifying distinct prognostic subtypes of clear cell renal cell carcinoma with differential response to tyrosine kinase inhibition. Eur Urol. 2015 Jan;67(1):17-20. doi: 10.1016/j.eururo.2014.06.041. Epub 2014 Jul 10. PubMed PMID: 25018036. JIF (2015): 14.976
  18. Lim WK, Ong CK, Tan J, Thike AA, Ng CC, Rajasegaran V, Myint SS, Nagarajan S, Nasir ND, McPherson JR, Cutcutache I, Poore G, Tay ST, Ooi WS, Tan VK, Hartman M, Ong KW, Tan BK, Rozen SG, Tan PH, Tan P, Teh BT. Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma. Nat Genet. 2014 Aug;46(8):877-80. doi: 10.1038/ng.3037. Epub 2014 Jul 20. PubMed PMID: 25038752. JIF (2014): 29.352
  19. Tan WJ, Lai JC, Thike AA, Lim JC, Tan SY, Koh VC, Lim TH, Bay BH, Tan MH, Tan PH. Novel genetic aberrations in breast phyllodes tumours: comparison between prognostically distinct groups. Breast Cancer Res Treat. 2014 Jun;145(3):635-45.  doi: 10.1007/s10549-014-2982-y. Epub 2014 May 16. PubMed PMID: 24831776. JIF (2014): 3.940
  20. Thike AA, Yong-Zheng Chong L, Cheok PY, Li HH, Wai-Cheong Yip G, Huat Bay B,  Tse GM, Iqbal J, Tan PH. Loss of androgen receptor expression predicts early recurrence in triple-negative and basal-like breast cancer. Mod Pathol. 2014 Mar;27(3):352-60. doi: 10.1038/modpathol.2013.145. Epub 2013 Aug 9. PubMed PMID:  23929266. JIF (2014): 6.187 



Atlas of Differential Diagnosis in Breast Pathology

ISBN-13: 978-1-4939-6695-0 (Print)
ISBN-10: 978-1-4939-6697-4 (Online)


Link: http://www.springer.com/us/book/9781493966950




WHO Classification of Tumours of the Breast

ISBN-13: 978-92-832-2433-4 (Print)
ISBN-13: 978-92-832-4489-9 (PDF)

ISBN-13: 978-92-832-4488-2 (EPUB) 

Link: http://publications.iarc.fr/Book-And-Report-Series/Who-Iarc-Classification-Of-Tumours/Who-Classification-Of-Tumours-Of-The-Breast-2012 


Fine Needle Aspiration Cytology of the Breast

ISBN-13: 978-3-642-35000-9 (Print)

ISBN-10: 978-3-642-34999-4


Link: http://www.springer.com/gp/book/9783642349997

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