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Thng Choon Hua
Dr Thng Choon Hua
National Cancer Centre Singapore
Division of Oncologic Imaging
Senior Consultant/Head
MBBS, FRCR (UK), FAMS

Dr. Choon Hua Thng received his MBBS from the National University of Singapore in 1989 and became a Fellow of the Royal College of Radiologists in 1996. He is a radiologist and is currently senior consultant and Head of the Division of Oncologic Imaging, National Cancer Centre, Singapore. He is an Adjunct Associate Professor with Duke-NUS Graduate Medical School and a Clinical Senior Lecturer with the Yong Loo Lin School of Medicine, National University of Singapore. Dr Thng’s research interests include Angiogenesis imaging, DCE MRI and Hepatobiliary MRI. He is a Principal Investigator holding research grants from the Singapore Cancer Syndicate (SCS-CS-0072) and the Biomedical Research Council (BMRC 08/1/31/19/577) for the use of DCE MRI for anti-angiogenic therapy and liver cancer.  He has also received industrial funding for projects involving microPET and microMRI imaging of animals. 

Professional Appointments and Committee Memberships
  • Deputy Head, Dept of Oncologic Imaging, National Cancer Centre, Singapore
  • Clinical Senior Lecturer, Yong Loo Lin School of Medicine, NUS
  • Adjunct Associate Professor, Duke-NUS Graduate Medical School

Publications and Research Trials

Publications

1. Hartono S, Thng CH, Ng QS, Yong CX, Yang CT, Shi W, Chuang KH, Koh TS. High temporal resolution dynamic contrast-enhanced MRI at 7 Tesla: A feasibility studwith mouse liver model. Conf Proc IEEE Eng Med Biol Soc. 2011 Aug;2011:2788-91.PubMed PMID: 22254920.


2. Koh TS, Bisdas S, Koh DM, Thng CH. Fundamentals of tracer kinetics for dynamic contrast-enhanced MRI. J Magn Reson Imaging. 2011 Dec;34(6):1262-76. doi:10.1002/jmri.22795. Epub 2011 Oct 3. PubMed PMID: 21972053.
3. Tan CH, Thng CH, Low AS, Tan VK, Hartono S, Koh TS, Goh BK, Cheow PC, Tan YM, Chung AY, Ooi LL, Earnest A, Chow PK. Wash-out of hepatocellular carcinoma: quantitative region of interest analysis on CT. Ann Acad Med Singapore. 2011 Jun;40(6):269-75. PubMed PMID: 21779615.
4. Koh TS, Thng CH, Hartono S, Choo SP, Ng QS, Khoo JB, Bisdas S, Koh DM. Deconvolution assessment of splenic and splanchnic contributions to portal venous blood flow in liver cirrhosis. Med Phys. 2011 May;38(5):2768-82. PubMed PMID:21776814.

5. Ng QS, Thng CH, Lim WT, Hartono S, Thian YL, Lee PS, Tan DS, Tan EH, Koh TS. Dynamic contrast-enhanced computed tomography in metastatic nasopharyngeal carcinoma: reproducibility analysis and observer variability of the distributed parameter model. Invest Radiol. 2012 Jan;47(1):5-10. PubMed PMID: 21577128.


6. Koh TS, Thng CH, Hartono S, Tai BC, Rumpel H, Ong AB, Sukri N, Soo RA, Wong CI, Low AS, Humerickhouse RA, Goh BC. A comparative study of dynamic contrast-enhanced MRI parameters as biomarkers for anti-angiogenic drug therapy. NMR Biomed. 2011 Nov;24(9):1169-80. doi: 10.1002/nbm.1680. Epub 2011 Mar 23.
PubMed PMID: 21432928.
7. Koh TS, Thng CH, Hartono S, Kwek JW, Khoo JB, Miyazaki K, Collins DJ, Orton MR, Leach MO, Lewington V, Koh DM. Dynamic contrast-enhanced MRI of neuroendocrine hepatic metastases: A feasibility study using a dual-input
two-compartment model. Magn Reson Med. 2011 Jan;65(1):250-60. PubMed PMID:20860001.
8. Thng CH, Koh TS, Collins DJ, Koh DM. Perfusion magnetic resonance imaging of the liver. World J Gastroenterol. 2010 Apr 7;16(13):1598-609. Review. PubMed PMID: 20355238; PubMed Central PMCID: PMC2848368.
9. Koh TS, Thng CH, Hartono S, Lee PS, Choo SP, Poon DY, Toh HC, Bisdas S. Dynamic contrast-enhanced CT imaging of hepatocellular carcinoma in cirrhosis:feasibility of a prolonged dual-phase imaging protocol with tracer kinetics modeling. Eur Radiol. 2009 May;19(5):1184-96. Epub 2009 Jan 10. PubMed PMID:19137312.
10. Koh TS, Thng CH, Lee PS, Hartono S, Rumpel H, Goh BC, Bisdas S. Hepatic metastases: in vivo assessment of perfusion parameters at dynamic contrast-enhanced MR imaging with dual-input two-compartment tracer kinetics
model. Radiology. 2008 Oct;249(1):307-20. Epub 2008 Aug 11. PubMed PMID:18695207.
 

Research Support

 

1. Biomedical Reseach Council (BMRC 08/1/31/19/577) 1 April 2009 to 31 March 2012

Role: PI

Validation and Use of the Distributed Parameter Tracer Kinetic Model for Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE MRI) of Hepatocellular Carcinoma.

 

2. Singapore Cancer Syndicate (SCS-CS-0072)  1 April 2006 to 31 March 2009

Role: PI

The use of dynamic contrast-enhanced MR Imaging (DCE MRI) and dynamic contrast-enhanced CT imaging (DCE CT) as a biomarker for effectiveness of anti-angiogenesis therapy. 

 

3. Co-investigator.  Biomedical Reseach Council (BMRC 02/1/22/17/264) 1 July 2003 to 30 June 2005

Role: Co-I

In Vivo Assessment of Neo-Angiogenesis and Microcirculatory Characteristics of Breast Carcinoma using Dynamic Contrast-Enhanced  Magnetic Resonance Imaging with Correlations to Histopathology. 

 

4. National Medical Research Council (NMRC1147/2007) 1 May 2008 to 1 May 2010

Role: Co-I

Development and testing of an image based pathology slicer with computer aided reconstruction for validation of imaging technologies and ground truth estimation.

 

5. National Medical Research Council  (NMRC 0859/2004) 1 Sep 2004 to 1 Aug 2007

Role: Co-I

MR-US registered robotic prostate biopsy. 

 

6. National Medical Research Council (NMRC0537/2001) 1 Jul 2001 to 1 June 2004

Role: Co-I

A robotic device for accurate prostate biopsy (using statistical model).

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